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The first major event
Accompanied by city leaders such as Fu Guirong, Executive Vice Mayor of Cixi City, and leaders of Fuhai Town of Cixi City, Peng Baoquan, chairman of China Household Electrical Appliances Business Association and relevant members of the association visit the Longwei Technology Exhibition Hall and He Shibing, chairman of Longwei Technology, at the scene To all levels of leaders one by one introduced my company's health, intelligence, water, fashion and other distinctive products, has been highly recognized by the leadership at all levels.

 

 

 

Hydrogen molecular medical knowledge spicy much, look at this one is enough! (Professor Xue-Jun Sun

Recent studies have found that hydrogen can effectively inhibit part of the active oxygen in the body and then produce antioxidant effects in animal experiments showed that a variety of oxidative stress-related diseases, good prevention and treatment and in preliminary clinical trials to achieve a similar control effect. The report about the biological effect of hydrogen has been reported from a few to many, showing a broad application prospect in the field of biomedicine. At present, the mechanism of action of hydrogen on prevention and treatment of diseases is not yet clear. The phenomenon of hydrogen prevention and treatment of various diseases is difficult to explain. Many researchers think that hydrogen may be the next such as nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) Yet another gas molecule with significant biological activity may have unique developmental advantages in disease control. In order to enhance the participation of the majority of delegates at meetings and to raise awareness and diagnosis and treatment of complex and difficult cases among medical staff in primary hospitals, the meeting set up a report on difficult and complicated cases and discussed them during the meeting Special We warmly welcome the active participation of relevant personnel from medical units all over the country and actively provide cases to participate in the discussion.


Key words: Hydrogen, Biological activity, Disease control, Antioxidant


Introduction:
Hydrogen is the smallest molecule in nature. For a long time, biologists mistakenly believe that it is a physiologically inert gas and can not react with biological substances. For example, in the field of diving medicine, using high-pressure hydrogen as a breathing medium is an advanced diving Technology, the world's largest diving depth record (700m) is the use of breathing hydrogen - oxygen mixture of diving.

 


Hydrogen is the smallest molecule in nature. For a long time, biologists mistakenly believe that it is a physiologically inert gas and can not react with biological substances. For example, in the field of diving medicine, using high-pressure hydrogen as a breathing medium is an advanced diving Technology, the world's largest diving depth record (700m) is the use of breathing hydrogen - oxygen mixture of diving.

 


They used a rat model of middle cerebral artery occlusion of cerebral ischemia reperfusion injury model and found that breathing a small amount of hydrogen (2%, breathing 35 minutes) can effectively remove animal oxidative damage end products, significantly improve the rat brain The volume of ischemic cerebral infarction and inhibition of microglial proliferation, the treatment of cerebral ischemia similar to immunosuppressive agents FK-506, the treatment effect was significantly surpassed the only clinically anti-oxidative drug epidural.

 


The advent of this report immediately aroused great attention of scholars at home and abroad, the hydrogen biological activity and the role in the prevention and treatment of various diseases quickly become a research hot spot, the prevention and treatment of hydrogen on a variety of other diseases have been studied by scholars.

 


For example, there is radiation injury to experimental animals, organ ischemia, arteriosclerosis, liver cirrhosis, oxygen poisoning, diabetes, organ and systemic inflammation, trauma, Parkinson's disease, senile dementia, carbon monoxide poisoning and paraquat poisoning, Good prevention and treatment of the role of the biomedical field to show a broad research and development prospects.

 


The discovery of hydrogen as a selective antioxidant has completely reversed the traditional view that hydrogen is a physiologically inert gas.

 


However, most of the current research focuses on the observation of the phenomenon of hydrogen disease prevention and control, and its mechanism of action is basically in the initial stage of research, still based on the anti-oxidation and anti-apoptosis of hydrogen, many phenomena Difficult to explain, with the further study of its mechanism of action, there may well be other unknown important role.

 


It is believed that the prevention and treatment of hydrogen on the injury will also have important new findings, combined with the existing research has not yet found the toxic side effects of hydrogen on the body, after a comprehensive and systematic evaluation of toxicology, it is very likely to be clinically promoted.

 

 

 

Discovery of hydrogen biological effects
At present, there are no enzymes in the human body that can catalyze the production of hydrogen and generally do not produce hydrogen in the body's metabolism. However, trace amounts of hydrogen, ie, endogenous hydrogen, exist in humans and higher animals.

 


Endogenous hydrogen comes from the metabolism of anaerobic bacteria in the body's large intestine. These bacteria degrade the unabsorbed polysaccharides in the gut and produce hydrogen through hydrogenase, which then diffuses through the gut to the body.

In the gut, bacteria can convert hydrogen to hydrogen sulfide (H2S), methane (CH4) and acetic acid (CH3COO?), Which are released from the lungs and skin outside the gut.

 


Under normal physiological conditions, anaerobic bacteria in the large intestine of the human body produces more than 12 liters of hydrogen per day, and the hydrogen concentration at the end of exhalation can reach 5-10 ppm. Higher concentrations of hydrogen, such as colon, gastric mucosa, liver and spleen, can also be detected in some tissues and organs of mice. The concentration of hydrogen in mouse liver can reach 42μM.

 


It is noteworthy that in the Ohsawa et al experiment, studies using a model of oxidative damage in PC12 cells showed that as long as the hydrogen concentration in the culture system reached 25 μmol / L (6 mmol / L hydrogen in an atmosphere at atmospheric pressure) A significant anti-oxidant effect.

 


This indicates that the level of endogenous hydrogen in the organism has reached the required level for the biological effect of hydrogen, implying that endogenous hydrogen may have certain physiological functions, for example, some of the side effects of antibiotics affecting the gut flora may be related to their inhibition The formation of endogenous hydrogen gas.

 


The famous French chemist Lavoisier was the first scientist to study the physiological role of hydrogen. As early as 1789, Lavoisier and Sequin had studied animal experiments with hydrogen as a respiratory medium.

 


In the experiment, Lavoisier and other guinea pigs into bell-shaped glass containers, so that the container to maintain a certain amount of nitrogen and oxygen, and then add hydrogen, guinea pigs in the container breathing hydrogen-nitrogen and oxygen ternary mixture, lasted 8- 10h, did not find any hydrogen from the outside world (exogenous hydrogen) to the body to bring any adverse effects.

 


In order to solve the problem of deep-seated nitrogen anesthesia and increase the depth of diving, scientists used hydrogen as a diving breathing gas to conduct human experimental research. For example, in 1937, British Case and Haldane exposed humans to 1.1 MPa pressure, breathing a mixture of hydrogen and oxygen for 5 minutes, and found no significant physiological changes.

 


In 1941, Lazarev et al., The Soviet Union, pressurized the mice to 9.1 MPa and breathed a mixture of hydrogen, nitrogen and oxygen for 3 min. After that, the mice were successfully decompressed for about 1 h. At several tens of atmospheres, Gas mixture to replace nitrogen, divers breathing hydrogen did not find any side effects.

 


In the field of radiation chemistry, Buxton et al. Found that hydrogen dissolved in water can reduce hydroxyl radicals from photolysis and radiation water sources, but no study has been done on whether hydrogen in the life system has the same effect.

 


In the field of diving medicine, there is a case where a diver breathes a few tens of atmospheres of high-pressure hydrogen gas during the diving process of the hydrogen-oxygen mixture. Thus, Kayar et al. Attempted to use isotope method in the hope that under high pressure conditions, hydrogen could be proved to dissolve in vivo Of oxygen or other high activity free radicals directly react, but because of the hydrogen can react less target material, their research without any discovery.

 


For a long time, diving physicians believe that hydrogen is a physiological inert gas, hydrogen in the body can not show the reduction, hydrogen can not react with any substance in the body. However, a few people still think that hydrogen has an anti-oxidant effect. Dole et al., The earliest report on the role of hydrogen in biology, found that continuous breathing of 97.5% of hydrogen at 8 atm resulted in a significant reduction of mouse cutaneous squamous cell carcinoma in two weeks, They hypothesized that hydrogen may be a free-radical catalyst. Due to the special experimental conditions, the repeatability is poor, and the study could not be continued.

 


Subsequently, Gharib et al found that hydrogen breathing at 7 atm had a significant therapeutic effect on the inflammation after liver parasitic infection in mice. It was the first time to prove that hydrogen has an anti-inflammatory effect and proposed that the direct reaction of hydrogen and OH is the molecular basis for the treatment of inflammatory damage. But they also did not start any follow-up research. Although these individual studies show some of the phenomena of hydrogen in the treatment of certain diseases, they have not drawn any interest from other scholars due to their unclear mechanism, lack of research, and high atmospheric pressure conditions.

 


Ohsawa et al., Which really made molecular hydrogen into the field of medical and life science research and quickly became the research hotspot. After years of in-depth research, they published research results in Nature Medicine in May 2007 and found that under a non-high pressure condition, a small amount of hydrogen can be administered to treat cerebral ischemia-reperfusion injury in rats and hydrogen is selectively oxidized Role of the point of view.

 


The so-called selective anti-oxidation means that hydrogen only reacts with OH and ONOO- and does not react with other reactive oxygen species that play a role in physiological processes such as O2-, H2O2 and NO.

 


Intracellular O2 and H2O2 are important signal transduction molecules, at the same time they regulate apoptosis, proliferation and differentiation and other physiological processes; H2O2 can be converted to hypochlorous acid by myeloperoxidase, the latter when the bacteria invade the body NO; is an important neurotransmitter and an important participant in vasodilatation.

 


Because hydrogen is more mildly reducible than interfering with the normal redox metabolism in the body, it is not sufficient to disrupt cellular signaling associated with reactive oxygen species, unlike many strongly reducing antioxidants that affect the body's essential physiological processes .

 


At present? OH is recognized as the most active free radical in the academic field, ONOO- activity was significantly higher than other reactive oxygen species. OH and ONOO- are much more active than other reactive oxygen species. Setsukinai et al. Studied the effects of OH, ONOO-, hypochlorite (ClO-), singlet oxygen (1O2), O2, H2O2 and NO, found that OH of the above three fluorescein reactivity 100 to 400 times other reactive oxygen species, and ONOO- reactivity 20 to 60 times that of other reactive oxygen species, mild reductive hydrogen only with these strongly free Base reaction.

 


In addition to its mild antioxidant effects, the high gas diffusion of hydrogen is not available with other antioxidants. Most antioxidants are currently unable to reach their targets efficiently, but hydrogen can easily penetrate biofilms to reach the cytoplasm, mitochondria And the nucleus, etc., effectively remove OH.

 


Therefore, from the theoretical analysis, the use of hydrogen gas may not have any side effects, compared with other antioxidants already have medical applications, the prospects may be more optimistic. Since the publication of the Ohsawa paper, the research on the bio-activity of hydrogen and the prevention and treatment of various diseases has shown a strong momentum of rapid development.

On the prevention and treatment of ischemia-reperfusion injury

Good blood circulation is to maintain the normal metabolism and function of the body tissues and organs of the necessary conditions, ischemia-reperfusion injury refers to a variety of reasons caused by the stop or decline in organ blood supply leading to tissue ischemia and hypoxia injury, but after the recovery of blood flow instead Leading to more serious tissue damage and inflammatory reactions.

 

 

 


Ischemia-reperfusion-induced increase in reactive oxygen species and lead to oxidative damage is considered to be an important mechanism of ischemia-reperfusion injury. During ischemia-reperfusion, the electron transport chain complex I (NADH dehydrogenase) and complex III (coenzyme Q-cytochrome c reductase) located on the mitochondrial inner membrane of the cells produce a large amount of O2- ·, Under the action of dismutase, O2 is converted to H2O2, and H2O2 is catalyzed to produce? OH in the presence of Fe2 + and Cu +.

 


OH will indiscriminately destroy nucleic acids, proteins and biofilms, resulting in lipid peroxidation, DNA oxidative damage and mitochondrial depolarization, which in turn leads to apoptosis and death of cells.

 


Ohsawa and other believe that the hydrogen and OH, generate non-toxic water molecules [H2 + OH = H2O + H], thereby reducing the ischemic reperfusion pathological oxidative damage during ischemia, to protect the purpose of ischemia-reperfusion organs.

 


Hydrogen-rich water has been used in animal experiments for various ischemia-reperfusion injuries. Hydrogen-rich water has been found to be ischemia-reperfused in the brain, including myocardium, liver, lung, intestine, kidney and retina When these organs can be significantly protected.

 


Another experiment also found that hydrogen can protect cognitive function after cerebral ischemia, treatment of subarachnoid hemorrhage, reduce the area of ​​myocardial infarction and cerebral infarction.

 


In addition to drinking hydrogen water, some people use the high diffusivity of hydrogen to diffuse hydrogen into a sealed saline bag to prepare hydrogen-rich physiological saline and prove that the injection of hydrogen-rich physiological saline has a significant therapeutic effect on stroke patients with brain stem.

 


At present, the mechanism of hydrogen to reduce ischemia-reperfusion injury is a selective antioxidant effect of hydrogen. In the above animal model, hydrogen significantly reduces the oxidative damage marker products such as 8-hydroxy-2-deoxyguanosine (8) -OHdG), malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) as the final lipid peroxidation products, and significantly reduce apoptosis and necrosis of focal tissue cells.

 


It should be pointed out that all the above studies only observed the effect of hydrogen therapy, such as reducing oxidative damage, ameliorating apoptosis, and protecting tissue function. There is no experimental evidence that hydrogen directly clears · OH produced in the lesion during ischemia-reperfusion, Hydrogen on the prevention and treatment mechanism of ischemia-reperfusion injury, a reasonable inference is its anti-oxidant effect, and more comprehensive and more precise mechanism of action needs further study.

 


There are also ischemia-reperfusion during transplantation, often resulting in inflammation of the transplanted organs, dysfunction, and even organ failure.

 


The good therapeutic effect of hydrogen on ischemia-reperfusion injury has led to the realization that hydrogen may also be used as an organ protectant in organ transplants.

 


In 2008, Nakao et al. First reported that continuous breathing of 2% hydrogen could prevent peristalsis after small bowel transplantation in rats, significantly enhance the contractility of jejunum smooth muscle and relieve the damage of intestinal mucosa morphology. The level of MDA in endoplasmic reticulum peroxidase , And the mRNAs of several important inflammatory molecules such as CCL2, IL1-beta, IL-6 and TNF-alpha were determined by quantitative PCR. (TNF-alpha) and found that hydrogen can significantly inhibit graft-induced inflammatory factor expression upregulation.

 


Subsequently, they also demonstrated that breathing hydrogen has a protective effect on heart injury, lung injury after lung transplantation, and chronic allograft nephropathy. In addition to antioxidation, they suggested that this protection of hydrogen gas may be related to enhancing the body's anti-inflammatory effect and inducing the antioxidant enzyme HO-1.

 


HO-1 is an antioxidant protein and also an enzyme that can produce CO, indicating that the biological effect of hydrogen may be achieved by increasing the concentration of CO, suggesting the potential effect of hydrogen on the CO signaling pathway. With the transplantation of organ preservation time extension

Share Chinese health big data, drinking water do not drink you look at it!

Data overview

160 million: There are 1.6-1.7 billion people with hypertension in China
100 million: There will be more than 100 million people with hyperlipidemia
92.4 million: 92.4 million people with diabetes
200 million: 70 million overweight or obese - 200 million people
160 million: 160 million people with dyslipidemia
120 million: about 120 million patients with fatty liver
30 seconds: An average person has cancer every 30 seconds
30 seconds: An average person has diabetes every 30 seconds
30 seconds: Every 30 seconds, at least one person dies of cardiovascular and cerebrovascular diseases
Chronic diseases and malignant tumors will become a deadly factor that threatens the health of Chinese people. In front of such a big data, you can be good at it?

 

Young disease

22%: 22% of middle-aged Chinese die of cardiovascular and cerebrovascular diseases;
Qicheng: Seventy percent of adults have the risk of death;
76%: white-collar sub-health rate as high as 76%;
Young women easily get gynecology, cardiovascular and cerebrovascular diseases;
Young men face sudden death, fatigue and cancer and other issues;
The prevalence of chronic diseases has reached 20%, the number of deaths accounted for 83% of the total number of deaths;
From 2013 to 2014, people aged 35 to 46 died of cardiovascular disease. China is 22% and the United States is 12%.

 

Medical big data

1/3: One in three patients died of adverse drug reactions.
40%: misdiagnosis rate of common diseases as high as 27%; misdiagnosis rate of major diseases as high as 40%.
85%: UK study confirms that: 85% of the drugs are ineffective, the best measures for patients is to minimize medical intervention.
The United States study confirmed that: a highly developed modern medical system and human health is not much.
American research confirms: 30% --- 40% of the surgery do not need to do!
American research confirms that only 10% of the factors related to the healthy lifespan of Americans are related to medical care! Of the 30 years leading to Americans' healthy life expectancy, 25 years have nothing to do with medicine.
The misdiagnosis rate of major diseases is so high, which is why each insurance company launched the secondary diagnosis and treatment of major diseases in recent years. Remember, blind governance is better than no cure.

 

720 defects a day

September 12, 2006 is China's first "Birth Prevention Day", the same year the monitoring showed that every 30 seconds there is a defective child born, the equivalent of 30 per hour, 720 per day!
In front of such a big data, you can rest assured that the second child? Especially after the four of the 70 post-70s. Pre-pregnancy and maternal and child health insurance are both indispensable.

 

Adolescent health data

80%: 80% Students breakfast poor nutritional quality.
38%: The incidence of adolescent anemia up to 38%.
50%: The incidence of fatty liver in children 40-50%.
80%: pupil myopia rate of 32.5%, junior high school students 59.4%, high school students 77.3%, 80% of college students.
65%: According to a survey conducted by the Chinese Academy of Preventive Medicine, the protein intake of 270 million students in China is only 65% ​​of the standard. Iron, calcium, zinc serious shortage of vitamin A intake of only 15% of the standard.

 

Elderly health data

In 2020, our country will enter a serious stage of aging.
Osteoporosis has leapt to common disease, frequently-occurring seventh.
The prevalence of over 60 years of age is 56% and the incidence of women is 60-70%. The incidence of fractures is close to one-third, with annual medical expenses of RMB 15 billion according to the most conservative estimates.
More than 24 million dementia patients in the world have reached an average of one every seven seconds. Alzheimer's patients in China account for about 1/4 of the total number of cases in the world, with an average annual increase of 300,000 new cases.
When the developed countries entered the stage of aging, the per capita GDP was between 5,000 and 8,000 U.S. dollars. In 2003, China was not rich before it was prosperous and its per capita GDP was 1,000 U.S. dollars.
After reading the lengthy data, I believe everyone's mind is not taste. The data is dead, and every single case after the data is alive. Looks bright and beautiful, what day big data it? Do not say you hide.
When an accident happens to someone else, it is a story; when it happens, it is a disaster.
In the frequent water pollution today
A word:


Water purifier is the patron saint of your family water!

Installed platform water purifier,

Is for their own health considerations,

Is responsible for the family!

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